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1

Structural and Functional Analysis of the Regulator of G Protein Signaling 2-Gαq Complex

Nance, Mark R., Kreutz, Barry, Tesmer, Valerie M., Sterne-Marr, Rachel, Kozasa, Tohru, Tesmer, John J.G.

Journal:

Year:

2013

Language:

english

File:

PDF, 1.60 MB

english, 2013

2

Strike a pose: Gαq complexes at the membrane

Lyon, Angeline M., Taylor, Veronica G., Tesmer, John J.G.

Journal:

Trends in Pharmacological Sciences

Year:

2014

Language:

english

File:

PDF, 2.75 MB

english, 2014

3

An autoinhibitory helix in the C-terminal region of phospholipase C-β mediates Gαq activation

Lyon, Angeline M, Tesmer, Valerie M, Dhamsania, Vishan D, Thal, David M, Gutierrez, Joanne, Chowdhury, Shoaib, Suddala, Krishna C, Northup, John K, Tesmer, John J G

Journal:

Nature Structural and Molecular Biology

Year:

2011

Language:

english

File:

PDF, 946 KB

english, 2011

4

[Methods in Pharmacology and Toxicology] G Protein-Coupled Receptor Kinases || G Protein-Coupled Receptor Kinases (GRKs) History: Evolution and Discovery

Gurevich, Vsevolod V., Gurevich, Eugenia V., Tesmer, John J.G.

Year:

2016

Language:

english

File:

PDF, 468 KB

english, 2016

5

[Methods in Pharmacology and Toxicology] G Protein-Coupled Receptor Kinases ||

Gurevich, Vsevolod V., Gurevich, Eugenia V., Tesmer, John J.G.

Year:

2016

Language:

english

File:

PDF, 8.12 MB

english, 2016

6

A Receptor on Acid

Chen, Qiuyan, Tesmer, John J.G.

Journal:

Year:

2017

Language:

english

File:

PDF, 574 KB

english, 2017

7

Structure-Based Design of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors Based on Paroxetine

Waldschmidt, Helen V., Homan, Kristoff T., Cato, Marilyn C., Cruz-Rodríguez, Osvaldo, Cannavo, Alessandro, Wilson, Michael W., Song, Jianliang, Cheung, Joseph Y., Koch, Walter J., Tesmer, John J. G.,

Journal:

Journal of Medicinal Chemistry

Year:

2017

Language:

english

File:

PDF, 1.28 MB

english, 2017

8

Structure of the C-terminal guanine nucleotide exchange factor module of Trio in an autoinhibited conformation reveals its oncogenic potential

Bandekar, Sumit J., Arang, Nadia, Tully, Ena S., Tang, Brittany A., Barton, Brenna L., Li, Sheng, Gutkind, J. Silvio, Tesmer, John J. G.

Journal:

Science Signaling

Year:

2019

Language:

english

File:

PDF, 908 KB

english, 2019

9

Guanylyl cyclase sees the light

Journal:

Journal of Biology

Year:

2008

Language:

english

File:

PDF, 504 KB

english, 2008

10

Preliminary x-ray analysis of Escherichia coli GMP synthetase: Determination of anomalous scattering factors for a cysteinyl mercury derivative

John J. G. Tesmer, Tim L. Stemmler, James E. Penner-Hahn, V. Jo Davisson, Dr. Janet L. Smith

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

1994

Language:

english

File:

PDF, 994 KB

english, 1994

11

Protostelids from German Beech forests

Jens Tesmer, Björn Rulik, Frederick W. Spiegel, John Shadwick, Martin Schnittler

Journal:

Mycological Progress

Year:

2005

Language:

english

File:

PDF, 495 KB

english, 2005

12

Differential modulation of mu-opioid receptor signaling to adenylyl cyclase by regulators of G protein signaling proteins 4 or 8 and 7 in permeabilised C6 cells is Gα subtype dependent

Jeffery N. Talbot, David L. Roman, Mary J. Clark, Rebecca A. Roof, John J. G. Tesmer, Richard R. Neubig, John R. Traynor

Journal:

Journal of Neurochemistry

Year:

2010

Language:

english

File:

PDF, 429 KB

english, 2010

13

Molecular basis for activation of G protein-coupled receptor kinases

Boguth, Cassandra A, Singh, Puja, Huang, Chih-chin, Tesmer, John J G

Journal:

The EMBO Journal

Year:

2010

Language:

english

File:

PDF, 2.31 MB

english, 2010

14

The crystal structure of GMP synthetase reveals a novel catalytic triad and is a structural paradigm for two enzyme families

Tesmer, John J.G., Klem, Thomas J., Deras, Michael L., Davisson, V. Jo, Smith, Janet L.

Journal:

Natural Structural Biology

Year:

1996

File:

PDF, 2.09 MB

1996

15

A seminal study of soluble adenylyl cyclase

Tesmer, John J G

Journal:

Nature Structural and Molecular Biology

Year:

2005

Language:

english

File:

PDF, 806 KB

english, 2005

16

The quest to understand heterotrimeric G protein signaling

Tesmer, John J G

Journal:

Nature Structural and Molecular Biology

Year:

2010

Language:

english

File:

PDF, 438 KB

english, 2010

17

Cluster cytometry for high-capacity bioanalysis

Bruce S. Edwards, Jingshu Zhu, Jun Chen, Mark B. Carter, David M. Thal, John J.G. Tesmer, Steven W. Graves, Larry A. Sklar

Journal:

Cytometry Part A

Year:

2012

Language:

english

File:

PDF, 1.56 MB

english, 2012

18

A conserved hydrophobic surface of the LARG pleckstrin homology domain is critical for RhoA activation in cells

Mohamed Aittaleb, Guang Gao, Chris R. Evelyn, Richard R. Neubig, John J.G. Tesmer

Journal:

Cellular Signalling

Year:

2009

Language:

english

File:

PDF, 3.16 MB

english, 2009

19

Gαq allosterically activates and relieves autoinhibition of p63RhoGEF

Aruna Shankaranarayanan, Cassandra A. Boguth, Susanne Lutz, Christiane Vettel, Franca Uhlemann, Mohamed Aittaleb, Thomas Wieland, John J.G. Tesmer

Journal:

Cellular Signalling

Year:

2010

Language:

english

File:

PDF, 2.66 MB

english, 2010

20

G protein-coupled receptor kinases: More than just kinases and not only for GPCRs

Eugenia V. Gurevich, John J.G. Tesmer, Arcady Mushegian, Vsevolod V. Gurevich

Journal:

Pharmacology & Therapeutics

Year:

2012

Language:

english

File:

PDF, 1.60 MB

english, 2012

21

Protein-ligand energetics assessed using deoxy and fluorodeoxy sugars in equilibrium binding and high resolution crystallographic studies

Polly S. Vermersch, John J.G. Tesmer, Florante A. Quiocho

Journal:

Journal of Molecular Biology

Year:

1992

Language:

english

File:

PDF, 5.32 MB

english, 1992

22

Self-masking in an Intact ERM-merlin Protein: An Active Role for the Central α-Helical Domain

Qianzhi Li, Mark R. Nance, Rima Kulikauskas, Kevin Nyberg, Richard Fehon, P. Andrew Karplus, Anthony Bretscher, John J.G. Tesmer

Journal:

Journal of Molecular Biology

Year:

2007

Language:

english

File:

PDF, 2.63 MB

english, 2007

23

Molecular Mechanism for Inhibition of G Protein-Coupled Receptor Kinase 2 by a Selective RNA Aptamer

Valerie M. Tesmer, Sabine Lennarz, Günter Mayer, John J.G. Tesmer

Journal:

Year:

2012

Language:

english

File:

PDF, 1.02 MB

english, 2012

24

Structure of RGS4 Bound to AlF4−-Activated Giα1: Stabilization of the Transition State for GTP Hydrolysis

John J.G. Tesmer, David M. Berman, Alfred G. Gilman, Stephen R. Sprang

Journal:

Year:

1997

Language:

english

File:

PDF, 617 KB

english, 1997

25

The interactions of adenylate cyclases with P-site inhibitors

Carmen W Dessauer, John J.G Tesmer, Stephen R Sprang, Alfred G Gilman

Journal:

Trends in Pharmacological Sciences

Year:

1999

Language:

english

File:

PDF, 357 KB

english, 1999

26

The structure, catalytic mechanism and regulation of adenylyl cyclase

John JG Tesmer, Stephen R Sprang

Journal:

Current Opinion in Structural Biology

Year:

1998

Language:

english

File:

PDF, 733 KB

english, 1998

27

Substrate-Induced Changes in the Dynamics of Rhodopsin Kinase (G Protein-Coupled Receptor Kinase 1)

Orban, Tivadar, Huang, Chih-chin, Homan, Kristoff T., Jastrzebska, Beata, Tesmer, John J. G., Palczewski, Krzysztof

Journal:

Year:

2012

Language:

english

File:

PDF, 2.23 MB

english, 2012

28

Membrane Orientation of Gα i β 1 γ 2 and Gβ 1 γ 2 Determined via Combined Vibrational Spectroscopic Studies

Yang, Pei, Boughton, Andrew, Homan, Kristoff T., Tesmer, John J. G., Chen, Zhan

Journal:

Journal of the American Chemical Society

Year:

2013

Language:

english

File:

PDF, 548 KB

english, 2013

29

[Progress in Molecular Biology and Translational Science] Molecular Biology of RGS Proteins Volume 86 || Chapter 4 Structure and Function of Regulator of G Protein Signaling Homology Domains

Tesmer, John J.G.

Year:

2009

Language:

english

File:

PDF, 934 KB

english, 2009

30

Activation of G Protein-Coupled Receptor Kinase 1 Involves Interactions between Its N-Terminal Region and Its Kinase Domain

Huang, Chih-chin, Orban, Tivadar, Jastrzebska, Beata, Palczewski, Krzysztof, Tesmer, John J. G.

Journal:

Year:

2011

Language:

english

File:

PDF, 1.04 MB

english, 2011

31

Insights into congenital stationary night blindness based on the structure of G90D rhodopsin

Singhal, Ankita, Ostermaier, Martin K, Vishnivetskiy, Sergey A, Panneels, Valérie, Homan, Kristoff T, Tesmer, John J G, Veprintsev, Dmitry, Deupi, Xavier, Gurevich, Vsevolod V, Schertler, Gebhard F X,

Journal:

Year:

2013

Language:

english

File:

PDF, 1.87 MB

english, 2013

32

The Role of Gβγ and Domain Interfaces in the Activation of G Protein-Coupled Receptor Kinase 2 †

Lodowski, David T., Barnhill, Jennifer F., Pyskadlo, Robyn M., Ghirlando, Rodolfo, Sterne-Marr, Rachel, Tesmer, John J. G.

Journal:

Year:

2005

Language:

english

File:

PDF, 775 KB

english, 2005

33

Structural insights into G protein-coupled receptor kinase function

Homan, Kristoff T, Tesmer, John JG

Journal:

Current Opinion in Cell Biology

Year:

2014

Language:

english

File:

PDF, 1.96 MB

english, 2014

34

Non-Canonical Modular Domain Interactions Dictate PKCα Function

Swanson, Carter J., Ritt, Michael, Wang, William, Lang, Michael, Tesmer, John J., Westfall, Margaret, Sivaramakrishnan, Sivaraj

Journal:

Biophysical Journal

Year:

2014

Language:

english

File:

PDF, 41 KB

english, 2014

35

Constitutively active rhodopsin mutants causing night blindness are effectively phosphorylated by GRKs but differ in arrestin-1 binding

Vishnivetskiy, Sergey. A., Ostermaier, Martin K., Singhal, Ankita, Panneels, Valerie, Homan, Kristoff T., Glukhova, Alisa, Sligar, Stephen G., Tesmer, John J.G., Schertler, Gebhard F.X., Standfuss, Jo

Journal:

Cellular Signalling

Year:

2013

Language:

english

File:

PDF, 918 KB

english, 2013

36

Unveiling the Membrane-Binding Properties of N-Terminal and C-Terminal Regions of G Protein-Coupled Receptor Kinase 5 by Combined Optical Spectroscopies

Ding, Bei, Glukhova, Alisa, Tesmer, John J.G., Chen, Zhan

Journal:

Biophysical Journal

Year:

2014

Language:

english

File:

PDF, 97 KB

english, 2014

37

In Situ Investigation of Heterotrimeric G Protein βγ Subunit Binding and Orientation on Membrane Bilayers

Chen, Xiaoyun, Boughton, Andrew P., Tesmer, John J. G., Chen, Zhan

Journal:

Journal of the American Chemical Society

Year:

2007

Language:

english

File:

PDF, 113 KB

english, 2007

38

Modulation of the Affinity and Selectivity of RGS Protein Interaction with G α Subunits by a Conserved Asparagine/Serine Residue †

Posner, Bruce A., Mukhopadhyay, Suchetana, Tesmer, John J., Gilman, Alfred G., Ross, Elliott M.

Journal:

Year:

1999

Language:

english

File:

PDF, 94 KB

english, 1999

39

Unveiling the Membrane-Binding Properties of N-Terminal and C-Terminal Regions of G Protein-Coupled Receptor Kinase 5 by Combined Optical Spectroscopies

Ding, Bei, Glukhova, Alisa, Sobczyk-Kojiro, Katarzyna, Mosberg, Henry I., Tesmer, John J. G., Chen, Zhan

Journal:

Year:

2014

Language:

english

File:

PDF, 2.93 MB

english, 2014

40

Structure of Human G Protein-Coupled Receptor Kinase 2 in Complex with the Kinase Inhibitor Balanol

Tesmer, John J. G., Tesmer, Valerie M., Lodowski, David T., Steinhagen, Henning, Huber, Jochen

Journal:

Journal of Medicinal Chemistry

Year:

2010

Language:

english

File:

PDF, 2.35 MB

english, 2010

41

Sugar-binding and crystallographic studies of an arabinose-binding protein mutant (Met108Leu) that exhibits enhanced affinity and altered specificity

Vermersch, Polly S., Lemon, Douglas D., Tesmer, John J. G., Quiocho, Florante A.

Journal:

Year:

1991

Language:

english

File:

PDF, 1.82 MB

english, 1991

42

A New Approach to Producing Functional Gα Subunits Yields the Activated and Deactivated Structures of Gα 12/13 Proteins †

Kreutz, Barry, Yau, Douglas M., Nance, Mark R., Tanabe, Shihori, Tesmer, John J. G., Kozasa, Tohru

Journal:

Year:

2006

Language:

english

File:

PDF, 489 KB

english, 2006

43

Identification and Structure–Function Analysis of Subfamily Selective G Protein-Coupled Receptor Kinase Inhibitors

Homan, Kristoff T., Larimore, Kelly M., Elkins, Jonathan M., Szklarz, Marta, Knapp, Stefan, Tesmer, John J. G.

Journal:

ACS Chemical Biology

Year:

2015

Language:

english

File:

PDF, 4.47 MB

english, 2015

44

Molecular Basis for P-Site Inhibition of Adenylyl Cyclase †,‡

Tesmer, John J. G., Dessauer, Carmen W., Sunahara, Roger K., Murray, Leyton D., Johnson, Roger A., Gilman, Alfred. G., Sprang, Stephen R.

Journal:

Year:

2000

Language:

english

File:

PDF, 334 KB

english, 2000

45

Molecular Basis for Small Molecule Inhibition of G Protein-Coupled Receptor Kinases

Homan, Kristoff T., Tesmer, John J. G.

Journal:

ACS Chemical Biology

Year:

2015

Language:

english

File:

PDF, 4.60 MB

english, 2015

46

Molecular Mechanisms of Phospholipase C β3 Autoinhibition

Lyon, Angeline M., Begley, Jessica A., Manett, Taylor D., Tesmer, John J.G.

Journal:

Year:

2014

Language:

english

File:

PDF, 2.37 MB

english, 2014

47

Full-length Gαq–phospholipase C-β3 structure reveals interfaces of the C-terminal coiled-coil domain

Lyon, Angeline M, Dutta, Somnath, Boguth, Cassandra A, Skiniotis, Georgios, Tesmer, John J G

Journal:

Nature Structural and Molecular Biology

Year:

2013

Language:

english

File:

PDF, 1.50 MB

english, 2013

48

Structure and function of lysosomal phospholipase A2 and lecithin:cholesterol acyltransferase

Glukhova, Alisa, Hinkovska-Galcheva, Vania, Kelly, Robert, Abe, Akira, Shayman, James A., Tesmer, John J. G.

Journal:

Nature Communications

Year:

2015

Language:

english

File:

PDF, 2.87 MB

english, 2015

49

Conserved Modular Domains Team up to Latch-open Active Protein Kinase Cα

Swanson, Carter J., Ritt, Michael, Wang, William, Lang, Michael J., Narayan, Arvind, Tesmer, John J., Westfall, Margaret, Sivaramakrishnan, Sivaraj

Journal:

Journal of Biological Chemistry

Year:

2014

Language:

english

File:

PDF, 3.65 MB

english, 2014

50

G Protein-coupled Receptor Kinases of the GRK4 Protein Subfamily Phosphorylate Inactive G Protein-coupled Receptors (GPCRs)

Li, Lingyong, Homan, Kristoff T., Vishnivetskiy, Sergey A., Manglik, Aashish, Tesmer, John J. G., Gurevich, Vsevolod V., Gurevich, Eugenia V.

Journal:

Journal of Biological Chemistry

Year:

2015

Language:

english

File:

PDF, 6.96 MB

english, 2015